Anti-alcohol action of hepaticoactivator (NKK-105) on motoricity and EEG in experimental animals and man.

The effects of a hepaticoactivator, diisopropyl 1, 3-dithiol-2-ylidene malonate (NKK-105), on motoricity and EEG were observed int he rat, mouse, cat and man. NKK-105 suppressed the effects of ethanol (1,000-3,000 mg/kg, p.o., in mice and rats), e.g. the blood alcohol concentration of NKK-105 treated subjects was significantly lower than that of untreated controls. NKK-105, in 100-300 mg/kg p.o. doses, significantly extended the clinging time on a glass rod, and the swimming time. Results indicate that NKK-105 inhibits the effects of alcohol, possibly by hepatic action, and to a lesser extent (neuro) motor activity, by reducing temulence. NKK-105 clearly exhibited anti-alcohol action (metabolic facilitory action) on EEG activity in experiments on cats and man. Almost complete blocking of alcohol action occurred in acute and chronic cats after NKK-105 (100 mg/kg, p.o., or 5-10 mg/kg , i.v.) treatment. It especially inhibited increased amplitude and/or increased slow components in cat neocortex recordings. Most human subjects showed similar results. It is concluded that the anti-alcohol action of NKK-105 seen in the EEG seems to be primarily a liver function, and secondarily a (neuro) motor function.